ALCOHOL CONTENT DETERMINATION – authorSTREAM Presentation. density, if you have density of your initial product you can estmate and also build a curve using etanol to the mix and know the final density later. If you know the. Two methods are adopted for the estimation of this. In one Traditionally, determination of alcohol in galenicals is carried out by distillation method followed by.
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ALCOHOL CONTENT DETERMINATION |authorSTREAM
WordPress Embed Customize Embed. Presentation Description No description available. Introduction Method I must be used for the determination of alcohol, unless otherwise specified in individual monograph. This method is useful for examining most fluid extracts and tinctures, provided ; The capacity of the distilling flask is sufficient commonly two to four times the volume of the liquid to be heated Rate of distillation is such that clear distillates are produced Troubleshooting the problems: Troubleshooting the problems Distillate should be clear.
If cloudy, add talc or CaCO 3 and filter, adjust temperature and determine the alcohol content from the specific gravity. Treat the liquids that froth to a troublesome extent during distillation by ; 1- Rendering them strongly acidic with H 3 PO 4H 2 SO 4tannic acid 2- Treating with a slight excess of calcium chloride solution or with a small amount of paraffin or silicon oil before starting the distillation.
Loss of alcohol by evaporation should be minimized. Prevent bumping during distillation by adding porous chips of insoluble material such as small pieces of broken glass, glass beads, porous chips or silicon carbide.
Add equal volume of water and distill.
US5288486A – Alcohol-based antimicrobial compositions – Google Patents
Collect distillate 2ml less than original volume of the test liquid 23mlalckhol the temperature at which the original test liquid was measuredadd water to make 25ml and mix.
The distillate must be clear and not more than slightly cloudy and does not contain more than traces of volatile substances other than alcohol and water. Add 50ml of water and distill.
Collect distillate 2ml less than original volume of the test liquid 48mladjust the temperature at which the original test liquid was measuredadd water to make 50ml and mix.
Special treatments Volatile acids and bases: Volatile acids and bases Render the preparations containing volatile bases slightly acidic with dilute sulphuric acid before distillation If volatile acids are present, render the preparation slightly alkaline with sodium hydroxide test solution Acidifying the bases or alkalinizing the acids causes them to be converted to alcohok form and form salts.
These salts then do not interfere with ethanol evaporation in distillation process.
Glycerin and iodine Glycerin: Chromatographic condition Carrier gas Helium or nitrogen Column packing Silica particles coated with polyethylene glycol Detector Flame Ionization Detector Alcohhol temperature Temperature of the column is maintained at o C Injection port temperature Temperature of the injection port o C Standard solutions: Add known concentration of internal standard acetone or acetonitrile unless otherwise specified in each.
Compare the peak response ratio. Determine peak response ratios.
USA – Alcohol-based antimicrobial compositions – Google Patents
Upload from Desktop Single File Upload. The presentation is successfully added In Your Favorites. Alcohll method is useful for examining most fluid extracts and tinctures, provided ; The capacity of the distilling flask is sufficient commonly two to four times the volume of the liquid to be heated Rate of distillation is such that clear distillates are produced.
Volatile acids and bases: Solution containing free iodine must be treated with; 1- Powdered zinc zinc iodide will be formed 2- Decolorize with sufficient sodium thiosulfate solution followed by few drops of sodium hydroxide. Chromatographic condition Carrier gas Helium or nitrogen Column packing Silica particles coated with polyethylene glycol Detector Alcohok Ionization Detector Column temperature Temperature of the column is maintained at o C Injection port temperature Temperature of the injection port o C.
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