CANCIDAS PACKAGE INSERT PDF

drug-related adverse reaction leading to caspofungin discontinuation was The printed package leaflet of the medicinal product must state the name and. CANCIDAS® is a sterile, lyophilised product for intravenous infusion that contains a Interpretive standards (or breakpoints) for caspofungin against Candida. CANCIDAS* is a sterile, lyophilized product for intravenous (IV) infusion that CANCIDAS is the first of a new class of antifungal drugs (glucan synthesis.

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Visually inspect prepared infusions for particulate matter and discoloration prior csncidas administration. Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.

Cholestasis, hepatic disease, hepatitis, jaundice.

Cancidas (caspofungin acetate) dose, indications, adverse effects, interactions from

Clinical practice guidelines suggest caspofungin as an alternative to posaconazole for aspergillosis prophylaxis in high-risk patients i. For fluid restricted patients, may dilute dose to a final concentration not to exceed 0. Beta 1,3 -D-glucan is not present in mammalian cells and therefore is an attractive target for antifungal activity.

In lung transplant recipients with tracheobronchial aspergillosis TBA associated with anastomotic endobronchial ischemia or ischemic reperfusion injury, inhaled amphotericin B deoxycholate is suggested in addition to systemic therapy; treat for at least 3 months or until TBA is resolved, whichever is longer.

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It has no activity against Cryptococcus neoformans, but in vitro has shown synergistic activity against C. Caution nisert advised when administering cancdias nursing mothers. Duration of treatment should be individualized to the indication, as described for each indication in adults [see Dosage and Administration 2.

Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions.

Caspofungin acetate (Cancidas ┬«) – GlobalRPH

Ineert for at least 6 to 12 weeks with duration dependent on extent and length of immunosuppression, infection site, and disease improvement. Animal studies reveal distribution primarily into the liver and kidneys. Invasive Aspergillosis A single mg loading dose should be administered on Day 1, followed by 50 mg daily thereafter. Caspofungin is contraindicated for use in patients with hypersensitivity cancias the drug or any of its components.

If this occurs, discontinue Caspofungin and administer appropriate treatment.

Isolated cases of hepatic dysfunction, hepatitis, or hepatic failure have been reported. Aspergillosis clinical practice guidelines suggest caspofungin as a first line empiric therapy. Theoretically, rifabutin and rifapentine could also decrease caspofungin blood concentrations.

The following organisms are generally considered susceptible to caspofungin in vitro: Fluconazole may be a potential alternative to consider during breast-feeding. Also recommended in patients with substantial risk of invasive candidiasis, such as allogeneic hematopoietic stem cell transplant HSCT recipients or those undergoing intensive remission-induction or salvage-induction chemotherapy for acute leukemia, and in patients with previous invasive aspergillosis, anticipated prolonged neutropenic periods of at least 2 weeks, or a prolonged period of neutropenia immediately prior to HSCT.

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There is no clinical experience in those with severe hepatic impairment Inser score more than 9, class C. The efficacy of a mg dose regimen in patients who are not clinically responding to the mg daily dose is not known.

Infants 1 to 2 months. Reference s National Institutes of Health, U. Empirical therapy should be continued until resolution of neutropenia.

Caspofungin Acetate for Injection Now Available from Fresenius Kabi

The mechanism of this interaction has not been identified but has been reported with tacrolimus; monitor sirolimus blood concentrations and adjust sirolimus dosage as required.

Limited data pwckage available. Moderate Use dichlorphenamide and caspofungin together with caution. Empirical therapy should be continued until neutropenia resolution. Clinical practice guidelines suggest caspofungin as salvage therapy. Longer courses greater than 6 months are frequently necessary. For invasive candidiasis with a metastatic focus, therapy will be longer and depends on response.

Currently, there are no established interpretive breakpoints for Aspergillus sp.

In murine models, caspofungin has been shown to have less activity against histoplasmosis than amphotericin B. Please see the full prescribing information for Caspofungin Acetate for Injection, including boxed warning, at http: Mix gently until the solution is clear.

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