Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.
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However, a breakdown in the mucosal barrier against gastric acid is not the only mechanism contributing to mucosal injury during NSAIDs administration. Previous studies have shown that some tannins Salawu et al. Several plants containing high amounts of saponins have been shown to possess antiulcer activity in several experimental bioassays Yamahara et al, ; Yesilada and Takaish, ; Morikawa et al, probably acting as an activator of mucus membrane protective factors Saito et al.
These were then processed routinely and the tissues febrlfuga embedded in paraffin wax. Six hours after piroxicam administration, the rats in all the groups were sacrificed under diethyl ether anesthesia. The authors are grateful to the management of National Institute for Pharmaceutical Research and Development for provision of enabling environment and facilities used for the study.
The Open Pharmacology Journal. Extensive mucosal atrophy noted, moderate infiltration by eosinophils and lymphoplasma cells of the wall. Ethanol-induced gastric ulceration The method described by Salawu et al. The lesions observed were assessed for the following; mucosal atrophy, presence of inflammatory cells in the wall, eosinophils, lymphocytes and plasma cells.
The extract profoundly antagonized the Piroxicam- induced ulceration in rats. Relation to gastric hypermotility. Crosskpteryx infiltration of inflammatory cells into mucosa areas.
Crossopteryx febrifuga – Useful Tropical Plants
Drugs that are effective against peptic ulcer act either febrifuya reducing the aggressive factors on the gastro-duodenal mucosa or by increasing mucosal resistance against them Larach febriuga Malagelada,Salawu et al. The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.
In the present study, the methanolic stem bark extract of Crossopteryx febrifuga was evaluated against ethanol- and piroxicam-induced ulceration in rats. Pharmacological screening and toxicology.
Crossopteryx – Wikipedia
Chemical and Pharmaceutical Bulletin. The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications. Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. Introduction Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al.
Preparation of the plant extract The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar. In the ethanol-induced ulcer assay, the control group treated orally with ethanol clearly produced the expected characteristic zone of necrotizing mucosal lesions.
Factors that may contribute to the protection of mucosa, such as mucus and bicarbonate secretion are dependent on gastric blood flow Guth et al. Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats.
Assessing African medicinal plants for efficacy and ctossopteryx It can thus be developed as a safe alternative to conventional non-steroidal anti-inflammatory drugs NSAIDs for the management of painful inflammatory disorders. Histopathological studies further confirmed crossoptwryx extract’s mucosal protective effect in that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in the wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas.
Ethanol retards gastric epithelial restoration in monolayer cultures. Thirty minutes later, all the rats in groups 2—6 were treated with piroxicam. Preventive ratio PR defined as the degree of protection offered by a treatment against ulcer causing agent was calculated using the formula:.
Oxygen free radical and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Corssopteryx studies using crude methanolic extract of C. Rubiaceae are widely used in Northern Nigeria in the therapeutic management of trypanosomiasis, malaria and painful inflammatory disorders.
Group 1 rats served as the normal control received no treatment. Yesilada E, Takaishi Y. Pharmacological studies of Panacis japonici Rhizoma. Traditional Complementary and Alternative Medicines Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats.
West African Plants
The method described by Salawu et al. Preparations of Crossopteryx febrifuga Afzel. Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. Previous studies have shown that the methanolic stem bark extract of Crossopteryx febrifuga possesses significant analgesic and anti-inflammatory properties possibly mediated via Non-selective inhibition of cyclo-oxygenase pathways. Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric crkssopteryx drugs.
Table 3 Results of Histopathology examinations.
The stem bark was cleaned, air-dried crozsopteryx seven 7 days and crushed into coarse powder using a pestle and mortar. Histopathology Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas.
National Center for Biotechnology InformationU. Effect of the extract on piroxicam-induced gastric ulceration Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats. Graph pad prism version 5. crosdopteryx
The studies were carried out following the principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No.