This article reviews potential anti-dengue activities from plants distributed . In the Philippines, Euphorbia hirta, known locally as “tawa–tawa”. Management of thrombocytopenia and flu-like symptoms in dengue patients with herbal water of Euphorbia hirta. Mir M, Khurshid R, Aftab R. BACKGROUND. PDF | Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue.

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Journal of Tropical Medicine. Natural Travel Health Network and Centre. The antiviral activity of U.

Potential anti-dengue medicinal plants: a review

The most commonly-used plants in the folkloric treatment of dengue in the Philippines include E. The use of herbs, however, is not a new phenomenon. Uncaria tomentosa Uncaria tomentosa belongs ehphorbia family Rubiaceae. Int J Antimicrob Agents.

Particularly for dengue, a commercial formulation capsule has been developed and the local communities in the Philippines consume it as a treatment for dengue [ 17 ]. Cryptonemia crenulata belongs to family Halymeniaceae.

Ann Clin Microbiol Antimicrob.

Each use reports maybe a specific disease state or a symptom. From the 76 use reports related to dengue symptoms, about corresponding dosage forms euphorbiaa E. During the period —, 12, dengue cases were reported, with a fatality rate of 3. All of them have established a significant platelet increasing activity following the administration of E. In vitro anti-dengue activity of Piper retrofractum in Vero cells was investigated [ 2 ].


Euphorbia hirta belongs to family Euphorbiaceae. Herbal medicines have a prudent use in dengue as a supportive therapy as effective antiviral drugs and vaccines for all stereotypes have not yet been developed. For instance, 3 respondents in Mt. Since dengke is no specific cure against hirt, treatment modalities include supportive measures to address specific symptoms.

Potential anti-dengue medicinal plants: a review

The survey, data gathering and analysis was conducted from April to June of The severity of dengue is amplified by the lack of effective treatment [ 7 ].

Table 1 Tally of use reports of E. The ready availability of E. The available evidence conclusively demonstrates the potential of E. It is estimated that around 50 million cases occur each year and more than 2.

Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence

Three animal studies conducted using rats and rabbits established that the subacute administration of E. The pentacyclic oxindole alkaloid-enriched fraction of U. Traditional medicines are euphorbja on knowledge, experience and practices based on indigenous cultural beliefs and knowledge, and are used to maintain health, prevent, treat and diagnose physical or mental illness [ 49 ].

Essential oils from Lippia alba and Lippia citriodora showed a considerable inhibitory effect on dengue virus serotype replication in Vero cells [ 23 ]. The chemical structures of ten of these different phytochemicals, isolated from 11 plants, denfue shown in Fig. De Guzman et al documented the use of E hirta for dengue among three indigenous groups in Pangasinan: Not a predominantly urban disease anymore.


Cymbopogon citratus belongs to family Poaceae. Biological characteristics of dengue virus and potential targets for drug design. Coumarin extract of A. The methanolic extract of A. Further, the effect of Yirta. Cytotoxicity studies were carried out to determine the MNTD in a virus inhibition assay.

Studies on the development of tetravalent vaccines are ongoing in Thailand and these should be available in the near future [ 6 ]. A significant increase of mean platelet count was also observed following the oral treatment for 9 days of water extract of E.

Journal of Tropical Medicine

It enters the cell by receptor-mediated endocytosis [ 15 ], with the cell membrane forming a sac-like structure known as an endosome. However, to identify potential anti-dengue plants or compounds, knowledge of the mechanisms of virus infection need to be understood inorder to facilitate the search for and development of the most appropriate drugs. Some respondents in Anda Island and Mt.

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