Langerhans cell histiocytosis: a rare cause of cholestasis in adult patients. Case report. Histiocitosis de Langerhans: causa infrecuente de colestasis en el. a Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Área de Neumopatías Intersticiales y Ocupacionales. Hospital Universitario Virgen del Rocío. Abstract. GOMEZ, ANA MARÍA et al. Langerhans cell histiocytosis in children. A description of 10 cases. CES Med. [online]. , vol, n.2, pp

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Continuing navigation will be considered as acceptance of this use. SJR uses a similar algorithm as the Google page rank; it provides langerbans quantitative and qualitative measure of the journal’s impact.

Accumulations of histiocytes are normally accompanied by fibrosis and a chronic inflammatory with a remarkable number of eosinophils 4,5. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact. When liver involvement is very important, however, and the above treatments could be toxic, the most effective option is liver transplant, which has low post-transplant relapse.

N Engl J Med,pp.

Histiocitosis de células de Langerhans en niños. Descripción de 10 casos

Go to the members area of the website of the AEDV, https: Histiocytosis; Langerhans cells; Pediatrics. Pemphigus Vegetans in the Inguinal Folds. Journal of Gastrointestinal and Liver Disease ; 15 1: The symptoms depend on the organ or organs involved. In the diagnosis by immunohistochemistry identified Langerhans Cell Histiocytosis, the cases were classified as multisystemic -multifocal in 5 patients, unisystemic in 1 patients – unifocal unisystemic in 1 patients -multifocal eosinophilic granuloma in 3 patients.


Liver transplantation in an adult with sclerosing cholangitis due to Langerhans cell histiocytosis. Of the 10 patients 5 had risk organ involvement and 1 died in the observation period.

It was informed a cholestasis due to long term obstruction of large biliary ducts. Therefore, langeerhans submission of manuscripts written in either Spanish or English is welcome.

Solitary congenital self-healing Langerhans cells histiocytosis. Subscriber If you already have your login data, please click here. Blanco 1C.

He had undergone a cholecistectomy and received treatment with levothyroxin, desmopressin and lamotrigine. Chest,pp. There are two patterns of involvement: Liver involvement can present as chronic cholestasis or space-occupying lesions 1.

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Subscribe to our Newsletter. Two newborns with a solitary lesion on the groin and shoulder respectively of Langerhans cell histiocytosis LCH showing spontaneous resolution are reported. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. SRJ is a prestige metric based on the idea that not all citations are the same. September Pages Pancreatic involvement is very rare.

Annals of Pediatrics is the Body of Scientific Expression of the Association and is the vehicle through which members communicate. There is no standard therapy in adults due to the low number of existing cases, so treatment will depend on the degree of involvement. The disease prognosis and its response to treatment is better in the single system form, particularly with bone involvement, and much worse in the multi-system form, especially if several risk organs are involved liver, spleen, bone marrow and lung.


Discussion There are two patterns of involvement: The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years.

The pathological diagnosis was chronic pancreatitis.

Gastrointestinal involvement in Langerhans cell histiocytosis. SRJ is a histiocitosks metric based on the idea that not all citations are the same. To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior.


The diagnosis is based on pathological study of a biopsy of the organ involved. Archivos de Bronconeumologia http: The patient’s liver function gradually worsened and he was taken to a centre of reference for a liver transplant, he died before it could be performed.

Subscribe to our Newsletter. Case report Histiocitosis de Langerhans: The main pathological finding is the presence of an accumulation of Langerhans histiocytes, which have distinctive nuclei features a central “coffee bean” shaped folding, fine chromatin, and oval shaped nuclei that distinguishes them from conventional histiocytes. Langerhans cell histiocytosis is a rare disease with different clinical and pathological presentation, is clinically divided into three groups:

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