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CitePeer Related Articles http: It is said that GBE treatment could avoid drug-induced obesity.
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Morin treatment also increased the number of trabecular bones in DEX-induced rats. Body mineral density BMD was determined at proximal femurs using dual energy X-ray absorptiometry. Journal of Natural Medicines [24 Jul72 4: In the current study, we tested the hypothesis that Ginkgo biloba extract GBE prevented hyperinsulinism-induced glucose intolerance in hepatocytes.
The relative expression of osteogenic and bone resorption markers was determined by real-time polymerase chain reaction and Western blotting, respectively. Body weight was regularly monitored. Find all citations in this journal default. Gene Ontology GO Terms. Gene Ontology GO Terms. We investigated the effects of GBE on glucose consumption, glucokinase activity, and mRNA levels of key genes in glucose metabolism and the insulin signaling pathway.
It should be noted that, unlike rosiglitazone, GBE did not stimulate excessive glucose uptake as it improved glucose tolerance. CitePeer Related Articles http: Or filter your current search.
Furthermore, after analyzing gene expression, we suggest that GBE chiefly exerts its effects by stimulating IRS-2 transcription. No matching affiliation detected. 114188 Our aim is to investigate the potential therapeutic value of morin against osteoporosis and elucidate the mechanism of action. Here, we uncovered the therapeutic effect of morin against osteoporosis and demonstrated its suppressive action on the MAPK pathway in this disease.
Our data suggest that GBE has the potential to prevent insulin resistance and is a promising anti-diabetic drug. Read Article at publisher’s site. To better show its efficacy, we included a control group that was treated with rosiglitazone, a type of thiazolidinedione TZD.
The data indicated that GBE repressed glucose uptake under normal conditions, while it dramatically improved glucose tolerance under insulin-resistant conditions.
Pathological examination was performed by hematoxylin and eosin staining.